Neocortical Seizure Termination by Focal Cooling: Temperature Dependence and Automated Seizure Detection

Dynamic Mechanisms of Neocortical Focal Seizure Onset

Recent experimental and clinical studies have provided diverse insight into the mechanisms of human focal seizure initiation and propagation. Often these findings exist at different scales of observation, and are not reconciled into a common understanding. Here we develop a new, multiscale mathematical model of cortical electric activity with realistic mesoscopic connectivity. Relating the mode...

Advances in automated neonatal seizure detection

This chapter highlights the current approaches in automated neonatal seizure detection and in particular focuses on classifier based methods. Automated detection of neonatal seizures has the potential to greatly improve the outcome of patients in the neonatal intensive care unit. The electroencephalogram (EEG) is the only signal on which 100% of electrographic seizures are visible and thus is c...

Automated seizure detection: unrecognized challenges, unexpected insights.

One of epileptology's fundamental aims is the formulation of a universal, internally consistent seizure definition. To assess this aim's feasibility three signal analysis methods were applied to a seizure time series and performance comparisons were undertaken among them and with respect to a validated algorithm. One of the methods uses a Fisher's matrix weighted measure of the rate of paramete...

Unusual Seizure Evolution: Focal-General-Focal-General

Automated seizure detection systems and their effectiveness for each type of seizure

Epilepsy affects almost 1% of the population and most of the approximately 20-30% of patients with refractory epilepsy have one or more seizures per month. Seizure detection devices allow an objective assessment of seizure frequency and a treatment tailored to the individual patient. A rapid recognition and treatment of seizures through closed-loop systems could potentially decrease morbidity a...